It is well known that calcium supplementation and human health is an extremely important integrated component of the human body, with 99% of the body’s calcium being contained within the skeleton. Plasma calcium homeostasis plays a crucial role in maintaining the body’s vital activities, such as the maintenance of the skeleton, regulation of hormone secretion, transmission of nerve impulses, and vascular activity.

Several studies have shown that calcium supplementation has a protective effect on bone health, improving bone mineral density (BMD) and reducing the morbidity of osteoporosis and osteoporotic fractures in different genders and age-groups, and calcium is used in the treatment of osteoporosis. Calcium supplementation has also been found to reduce the risk of cardiovascular death in studies of cardiovascular disease. Galas et al. studied the effect of dietary calcium intake on colorectal cancer and concluded a 5% reduction in the risk of colorectal cancer with an increase in dietary calcium intake of 100 mg per day. In addition, calcium supplementation is considered a standard treatment for hypocalcaemia associated with postsurgical hypoparathyroidism, with better clinical results.

According to published estimates, over 50% of the world’s population has insufficient access to dietary calcium, which is regarded as a prevalent problem worldwide. It is especially important to consider calcium supplementation dosage, individual health conditions, and ways to safely improve calcium intake and status when necessary.

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